Rick and Morty vs. the Universe # 1, published by Oni Press, initiates the franchise's first major comic crossover event, in which Rick and Morty are forced to go on the run from every universe they have ever messed with after a bachelor party goes disastrously wrong.
- The Universal Wedding: Rick's old friend, the sentient entity Universe Prime (from the dimension where Rick and Morty "Cronenberg'd" Earth), has reached its universal "half-life" and is getting married to the female-presenting embodiment of the Parmesan Dimension.
- The Bachelor Party Fiasco: Universe Prime asks Rick to plan his bachelor party. True to form, Rick's involvement leads to chaos, the specifics of which result in a catastrophic turn of events.
- On the Run: Following the disaster, Rick and Morty find themselves hunted by literally every single universe they have ever angered or altered. They are forced to flee, but with the entire multiverse against them, escaping is nearly impossible.
- A Last Resort: To survive, Rick must resort to a desperate, epic measure that he had hoped never to use: a plan to "reboot the universe" by attempting to merge all universes together.
- Character Dynamics: The issue sets the stage for a character-driven event, with Morty dealing with the psychological weight of their past adventures, and the main story branching into tie-in issues that explore what Summer, Beth, and Jerry are doing during the crisis.
This issue is praised for its ability to balance "biting comedy and profound moments" within the typical Rick and Morty chaotic interdimensional style.