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Wild Cards Book #1: Heart Of The Matter (Epic Comics, September 1990) is the first issue in a four-part comic series adapting the original Wild Cards mosaic novel, edited by George R.R. Martin. The story is written by Lewis Shiner, Stephen Leigh, and Howard Waldrop, with art by Barry Kitson, Mickey Ritter, and others.
The story takes place in an alternate post-World War II New York City, decades after an alien "Wild Card" virus was unleashed in the sky in 1946. This virus has three random outcomes for those infected: 90% die (drawing the "black queen"), 9% are hideously mutated into "jokers," and a lucky 1% become "aces" with superhuman powers.
The plot of this first issue centers on a private investigator, Jay Ackroyd, who is hired to investigate the bombing of the tomb of "Jetboy," the legendary first hero of the Wild Card era who died trying to stop the virus's release.
The miniseries as a whole ties together multiple storylines from the original books, creating a continuous narrative focused on the mystery of the bomber and the societal struggles within the Wild Cards universe.