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Fantastic Four: Negative Zone # 1 2020 is an extra-sized one-shot that revisits one of the team's most dangerous discoveries. The issue is split into two distinct stories.
"Ethical Dilemmas in Modern Science"
Written by Mike Carey with art by Stefano Caselli, this story focuses on the consequences of Reed Richards' past scientific curiosity.
"What Are the Fantastix For?"
Written by Ryan North with art by Steve Uy, this story provides the first solo adventure for the Fantastix, a team of young heroes who took over the Baxter Building while the original FF were away.
This one-shot was part of a series of "point-one" style issues (including Grimm Noir and 4 Yancy Street) that expanded on the team's status following their 2018 return. It also served as a thematic bridge to the Annihilation: Scourge event, which saw the Sentry and other heroes battling a new threat within the Negative Zone.